The Science Behind

The World's First Approved Bee Vaccine

Dalan Animal Health understands how immunity in honeybees works. This has allowed us to develop an industry-first method to impart protection and improve resilience to brood disease.

How it works

The Dalan vaccine technology exposes queen bees to inactive (i.e., “dead”) bacteria, which enables the larvae hatched in the hive to resist infection.

Dalan can assist in creating a custom vaccination program for your operation that is compatible with a variety of commonly used queen cages.

The vaccine is mixed with queen candy.
Worker bees consume the vaccine with the queen candy which is then digested and transferred to the glands that produce the royal jelly.
Worker bees feed the royal jelly containing the vaccine to the queen bee.
The queen digests the royal jelly and the vaccine is transferred to her ovaries. She is then released into the hive.
The vaccine is transferred to the developing eggs.
The developing larvae (now vaccinated) are more immune to infection as they hatch.
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Queen survival

In tests, immune priming showed no negative impact on queen fitness.

Dickel F, Bos NMP, Hughes H, Martín-Hernández R, Higes M, Kleiser A and Freitak D (2022) The oral vaccination with Paenibacillus larvae bacterin can decrease susceptibility to American Foulbrood infection in honey bees—A safety and efficacy studyFront. Vet. Sci. 9:946237. doi: 10.3389/fvets.2022.946237


Honey quality

Our tests also show no negative impact on honey. Our product is chemical free, non-GMO, and organic.

Dalan Animal Health is using its platform technology to develop vaccines for multiple diseases.

“What this team is accomplishing will be the long term future of beekeeping. It’s the change and the direction that the industry has badly needed for some time and has patiently waited for.”