Colony Loss Relief Special Offer

Protect against losses with Dalan’s vaccine and get $500+ back 

Protect and invest in your hive health.

Dalan and The Bee Expo are committed to putting beekeepers and bees first. With alarming hive losses reported this year, we recognize the urgent need for both colony health and financial support for beekeepers. That’s why we’re partnering with major beekeeping retailers to offer a minimum $500 gift card when you purchase Dalan’s honeybee vaccine—helping you protect your colonies from disease and invest back into your operation.

DALAN'S HONEYBEE VACCINE

How It Works

The Dalan vaccine exposes queen bees to inactive (i.e., “dead”) bacteria, which enables the larvae hatched in the hive to resist infection.

Dalan can assist in creating a custom vaccination program for your operation that is compatible with a variety of commonly used queen cages. 

The vaccine is mixed with queen candy.
Worker bees consume the vaccine with the queen candy which is then digested and transferred to the glands that produce the royal jelly.
Worker bees feed the royal jelly containing the vaccine to the queen bee.
The queen digests the royal jelly and the vaccine is transferred to her ovaries. She is then released into the hive.
The vaccine is transferred to the developing eggs.
The developing larvae (now vaccinated) are more immune to infection as they hatch.
paenibacillus larvae bacterin
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Offer Terms

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RESOURCES

Videos

Honeybee Vaccine Webinar

Everything you need to know about the first ever honeybee, from how it works, how to use it, and safety and efficacy data.  

Step-By-Step Tutorial: How to Vaccinate Queens

Step-by-step instructions for preparing the queen candy for vaccination.

A Canadian Beekeepers' Blog

Ian Steppler shares his method for vaccinating queens. 

New Study Shows How Vaccination May Fight DWV

Dr. Humberto Boncristiani from Inside the Hive TV breaks down the findings of this new research and explains why it’s such a game-changer for beekeeping and honey bee health.

Articles

Why Vaccinate Your Honeybees?

Amy Franklin, MS, DVM
Contagious honey bee diseases can cause significant economic harm to the honey bee industry and devastate honey bee populations. For bacterial diseases, the use of antibiotics can result in bacterial resistance and negatively impact overall hive health. Vaccination can be a promising alternative to protect honey bee colonies and the food supply chain. Read the Article

Charles Linder: A Commercial Perspective

American Bee Journal
In the February 2025 edition of American Bee Journal, commercial beekeeper Charles Linder shares his perspective on the critical role of innovation in the beekeeping industry, giving special recognition to Dalan’s vaccine. Read the Article

Vaccine for Deformed Wing Virus

American Bee Journal
A new vaccine for AFB may have wider benefits. 
Read the Article

Frequently Asked Questions

The vaccine works through Transgenerational Immune Priming (TGIP), whereby the maternal insect passes immunity to her offspring. The vaccine, containing a killed pathogen, is administered orally to queen bee via workers. As she ingests it, pieces of the vaccine are transported to her ovaries where it is deposited in the eggs. The developing larvae are exposed to the vaccine and start to build up immunity before they hatch.

One vial of the vaccine is thoroughly mixed with 300g of queen candy. 6g of candy is placed in a queen cage containing 6-10 attendants and a mated queen. The cage is kept in a cool dark space with proper water exposure for 7 days while the attendants feed the queen. On day 8, the queen can be released into a hive or be placed in a queen bank.

Read the full package insert here: https://dalan.com/package-insert/

For assistance with creating a custom protocol for your operation, call us at 844-483-2526. 

The vaccine is conditionally licensed by the USDA and CFIA to prime larvae against mortality from Paenibacillus larvae. This bacteria is the causative agent of American Foulbrood Disease (AFB), a highly contagious and devastating disease that destroys the developing bee larvae. 

Learn more about new experimental data showing how vaccination significantly reduced DWV-B in a large commercial yard in American Bee Journal

 

No, the vaccine does not contain mRNA technology. The vaccine contains inactivated (dead) Paenibacillus larvae bacteria, the causative agent of American Foulbrood Disease. The vaccine does not contain any chemicals or harmful preservatives and is suitable for use in organic agriculture.

More information on the vaccine’s properties can be found in the package insert. 

The USDA and CFIA have approved the vaccine for use and reviewed Dalan’s data indicating that the vaccine is safe. After over 5 years of study using thousands of doses of vaccine, immune priming has never indicated a negative impact on queen fitness or honey composition.

View the safety data at USDA.gov.  

Yes, the vaccine is suitable for use in organic agriculture. It is non-GMO and does not containany chemicals or harmful preservatives.

The immunity is passed onto the queen’s offspring, but a new queen born from the hive will not be able to pass this immunity onto her offspring. The immunity lasts one generation. New queens born from the hive would need to be replaced with a vaccinated queen or removed from the hive to be vaccinated.

The vaccine does not kill the bacterium. Our AFB vaccine utilizes a dead bacterium to promote an immune response within the honeybee. Vaccination of the queen bee has been shown to limit disease by passing on immunity and/or stimulating immunity in newly hatched larvae (Transgenerational Immune Priming or TGIP).

No. This has not been assessed. We recommend vaccinating a fresh queen for 8 days outside of the hive, making sure her attendants have access only to the vaccinated candy. Removing a queen from the hive, vaccinating her for 8 days, and returning her to the hive is not recommended.

The immunity lasts one generation. We recommend requeening annually with vaccinated queens.

Safety and efficacy data is found on Dalan’s website at https://www.dalan.com/package-insert/. Other data and publications can be found here: https://www.dalan.com/media-publications/